Nephrin Rabbit Polyclonal Antibody (ER1803-67)

UNIPROT #

O60500

PROTEIN NAME

Nephrin

SYNONYMS

CNF antibody;Nephrin antibody;Nephrosis 1 congenital Finnish type antibody;Nephrosis 1, congenital, Finnish type (nephrin) antibody;NPHN antibody;NPHN_HUMAN antibody;NPHS 1 antibody;Nphs1 antibody;Renal glomerulus specific cell adhesion receptor antibody;Renal glomerulus-specific cell adhesion receptor antibody

SEQUENCE SIMILARITIES

Belongs to the immunoglobulin superfamily.

TISSUE SPECIFICITY

Specifically expressed in podocytes of kidney glomeruli.

DEVELOPMENTAL STAGE

In 23-week-old embryo found in epithelial podocytes of the periphery of mature and developing glomeruli.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated at Tyr-1193 by FYN, leading to the recruitment and activation of phospholipase C-gamma-1/PLCG1.

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

This gene encodes a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. The renal filtration barrier consists of fenestrated endothelial cells, the glomerular basement membrane, and the podocytes of epithelial cells. The gene is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. Mutations in this gene result in Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes. A defect in the gene for nephrin, NPHS1, is associated with congenital nephrotic syndrome of the Finnish type and causes massive amounts of protein to be leaked into the urine, or proteinuria. Nephrin is also required for cardiovascular development. Plays a role in skeletal muscle formation through regulation of myoblast fusion.