NEK6 Recombinant Rabbit Monoclonal Antibody [JE51-72] (ET7110-15)

UNIPROT #

Q9HC98

PROTEIN NAME

NEK6

SYNONYMS

Highly similar to cell cycle protein kinase CDC5/MSD2 antibody;NEK6 antibody;NEK6_HUMAN antibody;Never in mitosis A-related kinase 6 antibody;NIMA (Never In Mitosis Gene A) Related Kinase 6 antibody;NimA related protein kinase 6 antibody;NimA-related protein kinase 6 antibody;Protein kinase SID6 1512 antibody;Protein kinase SID6-1512 antibody;Putative serine threonine protein kinase antibody;Serine/threonine protein kinase Nek6 antibody;Serine/threonine-protein kinase Nek6 antibody;SID6 1512 antibody;SID61512 antibody

SEQUENCE SIMILARITIES

Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.

TISSUE SPECIFICITY

Ubiquitous, with highest expression in heart and skeletal muscle.

POST-TRANSLATIONAL MODIFICATION

Autophosphorylated. Phosphorylation at Ser-206 is required for its activation. Phosphorylated upon IR or UV-induced DNA damage. Phosphorylated by CHEK1 and CHEK2. Interaction with APBB1 down-regulates phosphorylation at Thr-210.

SUBCELLULAR LOCATION

Cytoplasm, Cytoskeleton, Microtubule, Nucleus.

FUNCTION

Serine/threonine-protein kinase Nek6 is an enzyme that in humans is encoded by the NEK6 gene. The Aspergillus nidulans 'never in mitosis A' (NIMA) gene encodes a serine/threonine kinase that controls initiation of mitosis. NIMA-related kinases (NEKs) are a group of protein kinases that are homologous to NIMA. Evidence suggests that NEKs perform functions similar to those of NIMA. It is a protein kinase which plays an important role in mitotic cell cycle progression. Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis. Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3. Phosphorylates KIF11 to promote mitotic spindle formation. Involved in G2/M phase cell cycle arrest induced by DNA damage. Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence.