NEDD4 Recombinant Rabbit Monoclonal Antibody [JE35-58] (HA721191)

UNIPROT #

P46934

PROTEIN NAME

NEDD4

SYNONYMS

Cell proliferation-inducing gene 53 protein antibody;E3 ubiquitin protein ligase Nedd4 antibody;E3 ubiquitin-protein ligase NEDD4 antibody;HECT-type E3 ubiquitin transferase NEDD4 antibody;KIAA0093 antibody;NEDD 4 antibody;NEDD-4 antibody;Nedd4 antibody;NEDD4_HUMAN antibody;Neural precursor cell expressed developmentally down regulated 4 antibody;Neural precursor cell expressed developmentally down-regulated protein 4 antibody;neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase antibody;PIG53 antibody;receptor-potentiating factor 1 antibody;RPF1 antibody

SUBCELLULAR LOCATION

Cytoplasm, Cell membrane.

FUNCTION

In vitro, NEDD4 has been shown to bind and ubiquitinate a number of ion channels and membrane transporters resulting in their subsequent endocytosis and degradation by the proteasome, including the epithelial sodium channel (ENaC), voltage-gated calcium and voltage-gated sodium channels. NEDD4 mediates ubiquitination and subsequent down-regulation of components of the epidermal growth factor (EGF) signalling pathway, such as HER3 and HER4 EGF receptors, and ACK. The fibroblast growth factor receptor 1 (FGFR1) undergoes NEDD4 mediated ubiquitination and down-regulation, and contains a novel site (VL***PSR) that binds the C2 and WW3 domain of NEDD4. There is a role for NEDD4 in viral budding via ubiquitination of viral matrix proteins for a number of viruses, and NEDD4 also interacts with components of the endocytic machinery required for budding. NEDD4 can also function independently of its ubiquitin ligase activity. NEDD4 interacts with VEGFR2, leading to the degradation of VEGFR2 irrespective of whether the HECT domain is catalytically active. NEDD4 can bind and ubiquitinate the epithelial sodium channel (ENaC), leading to down-regulation of sodium channel activity. However, in vivo studies have implicated the NEDD4 family member NEDD4-2 as the main ligase responsible for ENaC regulation.