NDUFS2 Recombinant Rabbit Monoclonal Antibody [PSH03-26] (HA721968)

UNIPROT #

O75306

PROTEIN NAME

NDUFS2

SYNONYMS

CI 49 antibody;CI 49kD antibody;CI-49kD antibody;Complex 1, mitochondrial respiratory chain, 49 KD subunit antibody;Complex I 49kD antibody;Complex I 49kDa subunit antibody;Complex I-49kD antibody;mitochondrial antibody;NADH dehydrogenase (ubiquinone) Fe S protein 2 49kDa antibody;NADH dehydrogenase (ubiquinone) Fe S protein 2, 49kDa (NADH coenzyme Q reductase) antibody;NADH dehydrogenase [ubiquinone] iron sulfur protein 2, mitochondrial antibody;NADH dehydrogenase [ubiquinone] iron-sulfur protein 2 antibody;NADH ubiquinone oxidoreductase 49 kDa subunit antibody;NADH ubiquinone oxidoreductase NDUFS2 subunit antibody;NADH-ubiquinone oxidoreductase 49 kDa subunit antibody;NADH:ubiquinone oxidoreductase core subunit S2 antibody;Ndufs2 antibody;NDUS2_HUMAN antibody

SUBCELLULAR LOCATION

Mitochondrion inner membrane.

FUNCTION

Mitochondrial complex I is the first multimeric complex of the respiratory chain that catalyzes the NADH oxidation with concomitant ubiquinone reduction and proton ejection out of the mitochondria. Mammalian mitochondrial complex I is an assembly of at least 43 different subunits. Seven of the subunits are encoded by the mitochondrial genome; the remainder are the products of nuclear genes. The iron-sulfur protein (IP) fraction of complex I is made up of 7 subunits, including NDUFS2. Dimethylation at Arg-118 by NDUFAF7 takes place after NDUFS2 assembles into the complex I, leading to the stabilization of the early intermediate complex.