NDUFS1 Recombinant Rabbit Monoclonal Antibody [PSH14-45] (HA723641)

UNIPROT #

P28331

PROTEIN NAME

NDUFS1

SYNONYMS

CI-75kD antibody;Complex I 75Kd antibody;Complex I, mitochondrial respiratory chain, 75 kD subunit antibody;Complex I-75kD antibody;mitochondrial antibody;NADH coenzyme Q reductase antibody;NADH dehydrogenase (ubiquinone) FeS protein 1 (75kD) (NADH coenzyme Q reductase) antibody;NADH ubiquinone oxidoreductase 75 kDa subunit mitochondrial antibody;NADH-ubiquinone oxidoreductase 75 kDa subunit antibody;NDUFS1 antibody;NDUS1_HUMAN antibody;PRO1304 antibody

SUBCELLULAR LOCATION

Mitochondrion inner membrane.

FUNCTION

NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial (NDUFS1) is an enzyme that in humans is encoded by the NDUFS1 gene. The encoded protein, NDUFS1, is the largest subunit of complex I, located on the inner mitochondrial membrane, and is important for mitochondrial oxidative phosphorylation. Mutations in this gene are associated with complex I deficiency. The protein encoded by this gene belongs to the complex I 75 kDa subunit family. Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. This protein is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized.