NDUFA8 Recombinant Rabbit Monoclonal Antibody [PSH21-96] (HA724265)

UNIPROT #

P51970

PROTEIN NAME

NDUFA8

SYNONYMS

CI 19KD antibody;CI PGIV antibody;CI-19kD antibody;CI-PGIV antibody;Complex I 19k antibody;Complex I 19kD antibody;Complex I PGIV antibody;Complex I PGIV subunit antibody;Complex I-19kD antibody;Complex I-PGIV antibody;MGC793 antibody;NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 8 (19kD PGIV) antibody;NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 8 19kDa antibody;NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 8 antibody;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 antibody;NADH ubiquinone oxidoreductase 19 kDa subunit antibody;NADH ubiquinone oxidoreductase PGIV subunit antibody;NADH-ubiquinone oxidoreductase 19 kDa subunit antibody;NDUA8_HUMAN antibody;NDUFA 8 antibody;NDUFA8 antibody;OTTHUMP00000022034 antibody;PGIV antibody

SUBCELLULAR LOCATION

Mitochondrion inner membrane, Mitochondrion intermembrane space, Mitochondrion.

FUNCTION

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 is an enzyme that in humans is encoded by the NDUFA8 gene. The NDUFA8 protein is a subunit of NADH dehydrogenase (ubiquinone), which is located in the mitochondrial inner membrane and is the largest of the five complexes of the electron transport chain. The human NDUFA8 gene codes for a subunit of Complex I of the respiratory chain, which transfers electrons from NADH to ubiquinone. NADH binds to Complex I and transfers two electrons to the isoalloxazine ring of the flavin mononucleotide (FMN) prosthetic arm to form FMNH2. The electrons are transferred through a series of iron-sulfur (Fe-S) clusters in the prosthetic arm and finally to coenzyme Q10 (CoQ), which is reduced to ubiquinol (CoQH2). The flow of electrons changes the redox state of the protein, resulting in a conformational change and pK shift of the ionizable side chain, which pumps four hydrogen ions out of the mitochondrial matrix.