NDRG2 Rabbit Polyclonal Antibody (ER1802-94)

UNIPROT #

Q9UN36

PROTEIN NAME

NDRG2

SYNONYMS

Antidepressant related protein ADRG123 antibody;Cytoplasmic protein Ndr1 antibody;DKFZp781G1938 antibody;FLJ25522 antibody;KIAA1248 antibody;N myc downstream regulated gene 2 antibody;N myc downstream regulator 2 antibody;NDR1 related protein NDR2 antibody;NDRG 2 antibody;NDRG family member 2 antibody;NDRG1 related protein antibody;NDRG2 antibody;NDRG2_HUMAN antibody;Protein NDRG2 antibody;Protein Syld709613 antibody;SYLD antibody;Syld709613 protein antibody

SEQUENCE SIMILARITIES

Belongs to the NDRG family.

TISSUE SPECIFICITY

Highly expressed in brain, heart, skeletal muscle and salivary gland, and moderately in kidney and liver. Expressed in dendritic cells, but not in other blood cells. Expression levels are low in pancreatic and liver cancer tissues; absent in meningioma. Expressed in low-grade gliomas but present at low levels in glioblastoma. Isoform 1 and isoform 2 are present in brain neurons and up-regulated in Alzheimer disease (at protein level).

DEVELOPMENTAL STAGE

Specifically expressed during dendritic cell differentiation (in vitro). Expression is low in fetal brain and increases during brain postnatal development.

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

The N-myc downstream regulated gene (NDRG) family is comprised of four members, namely NDRG1, NDRG2, NDRG3 and NDRG4, all of which share 57-65% homology. NDRG2 (NDRG family member 2), also known as SYLD, is a 371 amino acid protein that localizes to both the cytoplasm and the perinuclear region in neurons. Expressed at high levels in heart, brain, dendritic cells, salivary gland and skeletal muscle and at lower levels in liver and kidney, NDRG2 is thought to be involved in dendritic and neuronal cell differentiation and outgrowth. Additionally, NDRG2 expression is downregulated in a variety of carcinomas, including liver cancer, pancreatic cancer and meningioma, suggesting a possible role for NDRG2 in tumor suppression. NDRG2 is found in brain lesions of Alzheimer Disease (AD)-affected patients and is thought to be associated with the progression of AD. Five isoforms of NDRG2 exist due to alternative splicing events.