Applications
-
WB
-
IHC-P
REACTIVITY
-
Mouse
-
Rat
SPECIFICATIONS
Product Type
Rabbit polyclonal primary
Product Name
NaV1.8 Rabbit Polyclonal Antibody (ER1706-30)
Immunogen
Synthetic peptide within rat nav18 aa 1,907-1,956 / 1,956.
Host
Rabbit
Positive Control
Rat spinal cord lysate, mouse brain tissue.
Conjugation
Unconjugated
Clonality
Polyclonal
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 ug/ul
PURIFICATION
Protein A purified.
MOLECULAR WEIGHT
220 kDa
Isotype
IgG
APPLICATION DILUTION
-
WB
-
1:100-1:500
-
IHC-P
-
1:50-1:200
TARGET
UNIPROT #
PROTEIN NAME
NaV1.8
SYNONYMS
hPN3 antibody; mPN3 antibody; Peripheral nerve sodium channel 3 antibody; Pn3 (gene name) antibody; PN3 antibody; SCN10A antibody; SCNAA_HUMAN antibody; Sensory neuron sodium channel antibody; Sns (gene name) antibody; SNS antibody; Sodium channel protein type 10 subunit alpha antibody; Sodium channel protein type X alpha subunit antibody; Sodium channel protein type X subunit alpha antibody; Voltage-gated sodium channel alpha subunit Nav1.8 antibody; Voltage-gated sodium channel subunit alpha Nav1.8 antibody
SEQUENCE SIMILARITIES
Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.8/SCN10A subfamily.
TISSUE SPECIFICITY
Expressed in dorsal root ganglion and trigeminal ganglion.
POST-TRANSLATIONAL MODIFICATION
Ubiquitinated by NEDD4L; which promotes its endocytosis.; Phosphorylation at Ser-1452 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents.; Lacks the cysteine which covalently binds the conotoxin GVIIJ. This cysteine (position 815) is speculated in other sodium channel subunits alpha to be implied in covalent binding with the sodium channel subunit beta-2 or beta-4.
SUBCELLULAR LOCATION
Plasma membrane.
FUNCTION
Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms.