Rabbit polyclonal primary
NaV1.8 Rabbit Polyclonal Antibody (ER1706-30)
Synthetic peptide within rat nav18 aa 1,907-1,956 / 1,956.
Rat spinal cord lysate, mouse brain tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
hPN3 antibody; mPN3 antibody; Peripheral nerve sodium channel 3 antibody; Pn3 (gene name) antibody; PN3 antibody; SCN10A antibody; SCNAA_HUMAN antibody; Sensory neuron sodium channel antibody; Sns (gene name) antibody; SNS antibody; Sodium channel protein type 10 subunit alpha antibody; Sodium channel protein type X alpha subunit antibody; Sodium channel protein type X subunit alpha antibody; Voltage-gated sodium channel alpha subunit Nav1.8 antibody; Voltage-gated sodium channel subunit alpha Nav1.8 antibody
Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.8/SCN10A subfamily.
Expressed in dorsal root ganglion and trigeminal ganglion.
Ubiquitinated by NEDD4L; which promotes its endocytosis.; Phosphorylation at Ser-1452 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents.; Lacks the cysteine which covalently binds the conotoxin GVIIJ. This cysteine (position 815) is speculated in other sodium channel subunits alpha to be implied in covalent binding with the sodium channel subunit beta-2 or beta-4.
Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms.