UNIPROT #

Q6QIY3

PROTEIN NAME

NaV1.8

SYNONYMS

hPN3 antibody; mPN3 antibody; Peripheral nerve sodium channel 3 antibody; Pn3 (gene name) antibody; PN3 antibody; SCN10A antibody; SCNAA_HUMAN antibody; Sensory neuron sodium channel antibody; Sns (gene name) antibody; SNS antibody; Sodium channel protein type 10 subunit alpha antibody; Sodium channel protein type X alpha subunit antibody; Sodium channel protein type X subunit alpha antibody; Voltage-gated sodium channel alpha subunit Nav1.8 antibody; Voltage-gated sodium channel subunit alpha Nav1.8 antibody

SEQUENCE SIMILARITIES

Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.8/SCN10A subfamily.

TISSUE SPECIFICITY

Expressed in dorsal root ganglion and trigeminal ganglion.

POST-TRANSLATIONAL MODIFICATION

Ubiquitinated by NEDD4L; which promotes its endocytosis.; Phosphorylation at Ser-1452 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents.; Lacks the cysteine which covalently binds the conotoxin GVIIJ. This cysteine (position 815) is speculated in other sodium channel subunits alpha to be implied in covalent binding with the sodium channel subunit beta-2 or beta-4.

SUBCELLULAR LOCATION

Plasma membrane.

FUNCTION

Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms.