NAPSIN A Recombinant Rabbit Monoclonal Antibody [JE39-28] (HA721025)

UNIPROT #

O96009

PROTEIN NAME

NAPSIN A

SYNONYMS

Asp 4 antibody;ASP4 antibody;Aspartyl protease 4 antibody;KAP antibody;Kdap antibody;Kidney derived aspartic protease like protein antibody;NAP1 antibody;NAPA antibody;Napsa antibody;NAPSA_HUMAN antibody;Napsin 1 antibody;napsin A aspartic peptidase antibody;Napsin A precursor antibody;Napsin-1 antibody;Napsin-A antibody;Pronapsin A antibody;SNAPA antibody;TA01/TA02 antibody

SUBCELLULAR LOCATION

Secreted.

FUNCTION

This gene encodes a member of the peptidase A1 family of aspartic proteases. The encoded preproprotein is proteolytically processed to generate an activation peptide and the mature protease. The activation peptides of aspartic proteinases function as inhibitors of the protease active site. These peptide segments, or pro-parts, are deemed important for correct folding, targeting, and control of the activation of aspartic proteinase zymogens. The encoded protease may play a role in the proteolytic processing of pulmonary surfactant protein B in the lung and may function in protein catabolism in the renal proximal tubules. This gene has been described as a marker for lung adenocarcinoma and renal cell carcinoma. The pronapsin A gene is expressed predominantly in lung and kidney. Its translation product is predicted to be a fully functional, glycosylated aspartic proteinase precursor containing an RGD motif and an additional 18 residues at its C-terminus.