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N4BP1 Recombinant Rabbit Monoclonal Antibody [JE63-75] (HA722576)

Price: Regular price $385.00

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Catalog# HA722576

Rabbit Monoclonal to N4BP1

Tested for

  • WB

  • IF-Cell

  • IHC-P

  • FC

Reacts with

  • Mouse

  • Rat

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free

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Specifications

Product Type

Recombinant Rabbit monoclonal primary

Product Name

N4BP1 Recombinant Rabbit Monoclonal Antibody [JE63-75] (HA722576)

Immunogen

Recombinant protein within mouse n4bp1 aa 251-500 / 893.

Host

Rabbit

Positive Control

F9 cell lysate, C2C12 cell lysate, Neuro-2a cell lysate, PC-12 cell lysate, C2C12, mouse testis tissue, rat testis tissue.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

JE63-75

APPLICATION DILUTION

  • WB

  • 1:1,000

  • IF-Cell

  • 1:100

  • IHC-P

  • 1:1,000

  • FC

  • 1:1,000

PROPERTIES

Form

Liquid

Storage Condition

Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 99 kDa

Isotype

IgG

TARGET

UNIPROT #

Q6A037

PROTEIN NAME

N4BP1

SYNONYMS

FLJ31821 antibody;KIAA0615 antibody;MGC176730 antibody;N4BP1 antibody;N4BP1_HUMAN antibody;NEDD4 binding protein 1 antibody;NEDD4-binding protein 1 antibody

SUBCELLULAR LOCATION

Cytoplasm, cytosol, Nucleus, nucleolus, PML body.

FUNCTION

Potent suppressor of cytokine production that acts as a regulator of innate immune signaling and inflammation. Acts as a key negative regulator of select cytokine and chemokine responses elicited by TRIF-independent Toll-like receptors (TLRs), thereby limiting inflammatory cytokine responses to minor insults. In response to more threatening pathogens, cleaved by CASP8 downstream of TLR3 or TLR4, leading to its inactivation, thereby allowing production of inflammatory cytokines (By similarity). Acts as a restriction factor against some viruses, such as HIV-1: restricts HIV-1 replication by binding to HIV-1 mRNAs and mediating their degradation via its ribonuclease activity. Also acts as an inhibitor of the E3 ubiquitin-protein ligase ITCH: acts by interacting with the second WW domain of ITCH, leading to compete with ITCH's substrates and impairing ubiquitination of substrates (By similarity).

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