N Cadherin Recombinant Antibody [SY02-46] - Mouse IgG1 (Chimeric) (HA601464)

UNIPROT #

P19022

PROTEIN NAME

N Cadherin

SYNONYMS

CADH2_HUMAN antibody;Cadherin 2 antibody;Cadherin 2 N cadherin neuronal antibody;Cadherin 2 type 1 antibody;Cadherin 2 type 1 N cadherin neuronal antibody;Cadherin 2, type 1, N-cadherin (neuronal) antibody;Cadherin-2 antibody;Cadherin2 antibody;Calcium dependent adhesion protein neuronal antibody;CD325 antibody;CD325 antigen antibody;CDH2 antibody;CDHN antibody;CDw325 antibody;CDw325 antigen antibody;N cadherin 1 antibody;N-cadherin antibody;NCAD antibody;Neural cadherin antibody;OTTHUMP00000066304 antibody;OTTHUMP00000067378 antibody

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

Cadherins comprise a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. The classical cadherins, E-, N- and P-cadherin, consist of large extracellular domains characterized by a series of five homologous NH2 terminal repeats. The most distal of these cadherins is thought to be responsible for binding specificity, transmembrane domains and carboxy-terminal intracellular domains. The relatively short intracellular domains interact with a variety of cytoplasmic proteins, such as b-catenin, to regulate cadherin function. Members of this family of adhesion proteins include rat cadherin K (and its human homolog, cadherin-6), R-cadherin, B-cadherin, E/P cadherin and cadherin-5.