N-Cadherin Mouse Monoclonal Antibody [A10-4] (M1304-1)

UNIPROT #

P19022

PROTEIN NAME

N-Cadherin

SYNONYMS

CADH2_HUMAN antibody;Cadherin 2 antibody;Cadherin 2 N cadherin neuronal antibody;Cadherin 2 type 1 antibody;Cadherin 2 type 1 N cadherin neuronal antibody;Cadherin 2, type 1, N-cadherin (neuronal) antibody;Cadherin-2 antibody;Cadherin2 antibody;Calcium dependent adhesion protein neuronal antibody;CD325 antibody;CD325 antigen antibody;CDH2 antibody;CDHN antibody;CDw325 antibody;CDw325 antigen antibody;N cadherin 1 antibody;N-cadherin antibody;NCAD antibody;Neural cadherin antibody;OTTHUMP00000066304 antibody;OTTHUMP00000067378 antibody

POST-TRANSLATIONAL MODIFICATION

Cleaved by MMP24. Ectodomain cleavage leads to the generation of a soluble 90 kDa amino-terminal soluble fragment and a 45 kDa membrane-bound carboxy-terminal fragment 1 (CTF1), which is further cleaved by gamma-secretase into a 35 kDa. Cleavage in neural stem cells by MMP24 affects CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate neural stem cell quiescence (By similarity).; May be phosphorylated by OBSCN.

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

The cadherins are a large family of cell adhesion molecules involved in calcium-dependent recognition and adhesion events. The cadherin subfamily includes N-, P-, B-, and E- cadherins, and other members. Recent studies indicate that cancer cells have up-regulated N-cadherin in addition to loss of E-cadherin. This change in cadherin expression is called the "cadherin switch". N-cadherin cooperates with the FGF receptor, leading to overexpression of MMP-9 and cellular invasion.