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MyT1L Rabbit Polyclonal Antibody (HA500297)

Price: Regular price $315.00

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Catalog# HA500297

Rabbit Polyclonal to MyT1L

Tested for

  • WB

  • IHC-P

Reacts with

  • Human

  • Mouse

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Specifications

Product Type

Rabbit polyclonal primary

Product Name

MyT1L Rabbit Polyclonal Antibody (HA500297)

Immunogen

Recombinant protein within human myt1l aa 200-400 / 1186.

Host

Rabbit

Positive Control

SH-SY5Y cell lysates, mouse cerebellum tissue, mouse brain tissue.

Conjugation

Unconjugated

Clonality

Polyclonal

RRID

AB_3071392

APPLICATION DILUTION

  • WB

  • 1:1,000

  • IHC-P

  • 1:2,000-1:5,000

PROPERTIES

Form

Liquid

Storage Condition

Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.

Storage Buffer

1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Immunogen affinity purified.

Molecular Weight

Predicted band size: 133 kDa

Isotype

IgG

TARGET

UNIPROT #

Q9UL68

PROTEIN NAME

MyT1L

SYNONYMS

Myelin transcription factor 1-like protein antibody;MyT1-L antibody;MyT1L antibody;MYT1L_HUMAN antibody;neural zinc finger transcription factor 1 antibody

SUBCELLULAR LOCATION

Chromosome, Nucleus.

FUNCTION

Transcription factor that plays a key role in neuronal differentiation by specifically repressing expression of non-neuronal genes during neuron differentiation. In contrast to other transcription repressors that inhibit specific lineages, mediates repression of multiple differentiation programs. Also represses expression of negative regulators of neurogenesis, such as members of the Notch signaling pathway, including HES1. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Directly binds the 5'-AAGTT-3' core motif present on the promoter of target genes and represses transcription by recruiting a multiprotein complex containing SIN3B. The 5'-AAGTT-3' core motif is absent from the promoter of neural genes.

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