MyT1L Rabbit Polyclonal Antibody (HA500297)

UNIPROT #

Q9UL68

PROTEIN NAME

MyT1L

SYNONYMS

Myelin transcription factor 1-like protein antibody;MyT1-L antibody;MyT1L antibody;MYT1L_HUMAN antibody;neural zinc finger transcription factor 1 antibody

SUBCELLULAR LOCATION

Chromosome, Nucleus.

FUNCTION

Transcription factor that plays a key role in neuronal differentiation by specifically repressing expression of non-neuronal genes during neuron differentiation. In contrast to other transcription repressors that inhibit specific lineages, mediates repression of multiple differentiation programs. Also represses expression of negative regulators of neurogenesis, such as members of the Notch signaling pathway, including HES1. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Directly binds the 5'-AAGTT-3' core motif present on the promoter of target genes and represses transcription by recruiting a multiprotein complex containing SIN3B. The 5'-AAGTT-3' core motif is absent from the promoter of neural genes.