MYL4 Rabbit Polyclonal Antibody (HA500471)

UNIPROT #

P12829

PROTEIN NAME

MYL4

SYNONYMS

ALC 1 antibody;ALC1 antibody;AMLC antibody;Atrial/embryonic alkali myosin light chain antibody;embryonic muscle/atrial isoform antibody;GT 1 antibody;GT1 antibody;MLC 1 antibody;MLC1 antibody;MYL 4 antibody;Myl4 antibody;MYL4_HUMAN antibody;Myosin atrial/fetal muscle light chain antibody;Myosin light chain 1 antibody;Myosin light chain 1 embryonic muscle/atrial isoform antibody;Myosin light chain 4 alkali atrial embryonic antibody;Myosin light chain 4 antibody;Myosin light chain alkali GT 1 isoform antibody;Myosin light chain alkali GT-1 isoform antibody;Myosin light polypeptide 4 alkali atrial embryonic antibody;Myosin light polypeptide 4 antibody;PRO1957 antibody

SUBCELLULAR LOCATION

Myosin complex, cytosol, A band.

FUNCTION

Atrial Light Chain-1 (ALC-1), also known as Essential Light Chain, Atrial is a protein that in humans is encoded by the MYL4 gene. ALC-1 is expressed in fetal cardiac ventricular and fetal skeletal muscle, as well as fetal and adult cardiac atrial tissue. ALC-1 expression is reactivated in human ventricular myocardium in various cardiac muscle diseases, including hypertrophic cardiomyopathy, dilated cardiomyopathy, ischemic cardiomyopathy and congenital heart diseases. ALC-1 is expressed very early in skeletal muscle and cardiac muscle development; two E-boxes and CArG box in the MYL4 promoter region regulate transcription. ALC-1 expression in cardiac ventricles decreases in early postnatal development, but is highly expressed in atria throughout all of adulthood. Normal atrial function is essential for embryogenesis, as inactivation of the MYL7 gene was embryonic lethal at ED10.5-11.5. Evidence of ALC-1 isoform expression on contractile mechanics of sarcomeres came from experiments studying fibers from patients expressing a higher level of ALC-1 relative to VLC-1 in cardiac left ventricular tissue.