Myf5 Recombinant Rabbit Monoclonal Antibody [JE38-56] (HA722400)

UNIPROT #

P24699

PROTEIN NAME

Myf5

SYNONYMS

bHLHc2 antibody;Class C basic helix loop helix protein 2 antibody;Class C basic helix-loop-helix protein 2 antibody;Myf 5 antibody;Myf-5 antibody;Myf5 antibody;MYF5_HUMAN antibody;Myogenic factor 5 antibody

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Myogenic factor 5 is a protein that in humans is encoded by the MYF5 gene. It is a protein with a key role in regulating muscle differentiation or myogenesis, specifically the development of skeletal muscle. Myf5 belongs to a family of proteins known as myogenic regulatory factors (MRFs). These basic helix loop helix transcription factors act sequentially in myogenic differentiation. MRF family members include Myf5, MyoD (Myf3), myogenin, and MRF4 (Myf6). This transcription factor is the earliest of all MRFs to be expressed in the embryo, where it is only markedly expressed for a few days (specifically around 8 days post-somite formation and lasting until day 14 post-somite in mice). It functions during that time to commit myogenic precursor cells to become skeletal muscle. In fact, its expression in proliferating myoblasts has led to its classification as a determination factor. Furthermore, Myf5 is a master regulator of muscle development, possessing the ability to induce a muscle phenotype upon its forced expression in fibroblastic cells.