Myeloperoxidase Recombinant Rabbit Monoclonal Antibody [PD00-20] (HA721146)

UNIPROT #

P05164

PROTEIN NAME

Myeloperoxidase

SYNONYMS

84 kDa myeloperoxidase antibody;89 kDa myeloperoxidase antibody;EC 1.11.1.7 antibody;EC1.11.2.2 antibody;fj80f04 antibody;MPO antibody;mpx antibody;myeloid-specific peroxidase antibody;Myeloperoxidase antibody;Myeloperoxidase heavy chain antibody;Myeloperoxidase light chain antibody;PERM_HUMAN antibody;wu:fj80f04 antibody

SUBCELLULAR LOCATION

Lysosome.

FUNCTION

Myeloperoxidase (MPO) is a peroxidase enzyme that in humans is encoded by the MPO gene on chromosome 17. MPO is most abundantly expressed in neutrophil granulocytes (a subtype of white blood cells), and produces hypohalous acids to carry out their antimicrobial activity, including hypochlorous acid, the sodium salt of which is the chemical in bleach. It is a lysosomal protein stored in azurophilic granules of the neutrophil and released into the extracellular space during degranulation. Neutrophil myeloperoxidase has a heme pigment, which causes its green color in secretions rich in neutrophils, such as mucus and sputum. The green color contributed to its outdated name verdoperoxidase. Immunohistochemical staining for myeloperoxidase used to be administered in the diagnosis of acute myeloid leukemia to demonstrate that the leukemic cells were derived from the myeloid lineage. Myeloperoxidase staining is still important in the diagnosis of myeloid sarcoma, contrasting with the negative staining of lymphomas, which can otherwise have a similar appearance.