Myelin PLP Chicken Polyclonal Antibody (HA500573)

UNIPROT #

P60202

PROTEIN NAME

Myelin PLP

SYNONYMS

HLD1 antibody;Lipophilin antibody;Major myelin proteolipid protein antibody;MMPL antibody;Myelin proteolipid protein antibody;MYPR_HUMAN antibody;PLP 1 antibody;PLP antibody;PLP/DM20 antibody;PLP1 antibody;PMD antibody;Proteolipid protein 1 antibody;SPG2 antibody

SUBCELLULAR LOCATION

Cell membrane, Myelin membrane.

FUNCTION

Proteolipid protein 1 (PLP1) is a form of myelin proteolipid protein (PLP). Mutations in PLP1 are associated with Pelizaeus–Merzbacher disease. It is a 4 transmembrane domain protein which is proposed to bind other copies of itself on the extracellular side of the membrane. In a myelin sheath, as the layers of myelin wraps come together, PLP will bind itself and tightly hold the cellular membranes together. This gene encodes a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system (CNS). The encoded protein functions in myelination. This protein may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations associated with this gene cause X-linked Pelizaeus–Merzbacher disease and spastic paraplegia type 2. Two transcript variants encoding distinct isoforms have been identified for this gene. In melanocytic cells PLP1 gene expression may be regulated by MITF.