MOG Recombinant Rabbit Monoclonal Antibody [JM23-06] (ET1705-16)

UNIPROT #

Q16653

PROTEIN NAME

MOG

SYNONYMS

BTN6 antibody;BTNL11 antibody;MGC26137 antibody;MOG alpha 5 antibody;MOG alpha 6 antibody;MOG AluA antibody;MOG AluB antibody;MOG antibody;MOG Ig AluB antibody;MOG_HUMAN antibody;MOGIG2 antibody;Myelin oligodendrocyte glycoprotein antibody;Myelin-oligodendrocyte glycoprotein antibody;NRCLP7 antibody

SEQUENCE SIMILARITIES

Belongs to the immunoglobulin superfamily. BTN/MOG family.

TISSUE SPECIFICITY

Found exclusively in the CNS, where it is localized on the surface of myelin and oligodendrocyte cytoplasmic membranes.

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

Myelin oligodendrocyte glycoprotein (MOG) is a glycoprotein believed to be important in the myelination of nerves in the central nervous system (CNS). In humans this protein is encoded by the MOG gene. It is speculated to serve as a necessary "adhesion molecule" to provide structural integrity to the myelin sheath and is known to develop late on the oligodendrocyte. While the primary molecular function of MOG is not yet known, its likely role with the myelin sheath is either in sheath "completion and/or maintenance". More specifically, MOG is speculated to be "necessary" as an "adhesion molecule" on the myelin sheath of the CNS to provide the structural integrity of the myelin sheath."