MVP Recombinant Rabbit Monoclonal Antibody [JM74-73] (ET1705-69)

UNIPROT #

Q14764

PROTEIN NAME

MVP

SYNONYMS

LRP antibody;Lung resistance related protein antibody;Lung resistance-related protein antibody;Major vault protein antibody;Major vault protein, rat, homolog of antibody;MVP antibody;MVP_HUMAN antibody;testicular secretory protein Li 30 antibody;VAULT 1 antibody;VAULT1 antibody

TISSUE SPECIFICITY

Present in most normal tissues. Higher expression observed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many multidrug-resistant cancer cells.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated on Tyr residues after EGF stimulation.; Dephosphorylated by PTPN11.

SUBCELLULAR LOCATION

Cytoplasm, Nuclear pore complex, Nucleus.

FUNCTION

Major vault protein (MVP), is overexpressed in various multidrug-resistant cancer cell lines and clinical samples. The promoter of MVP is TATA-less; contains an inverted CCAAT-box and a Sp1 site located near a p53 binding motif. MVP has two alternative splice variants, which differ from each other within the 5'-leader. The long-MVP isoform is ubiquitously expressed and represents an almost constant portion of the total MVP mRNA in many different normal tissues. MVP is the major component of the multimeric ribonucleoprotein complexes, with several copies of an untranslated RNA, which has been shown to transport along cytoskeletal-based cellular tracks. In conclusion, MVP protein mediates drug resistance, perhaps via a transport process.