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Munc13-4 Rabbit Polyclonal Antibody (HA500052)

Price: Regular price $315.00

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Catalog# HA500052

Rabbit Polyclonal to Munc13-4

Tested for

  • WB

  • IF-Cell

  • IHC-P

Reacts with

  • Human

  • Rat

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Specifications

Product Type

Rabbit polyclonal primary

Product Name

Munc13-4 Rabbit Polyclonal Antibody (HA500052)

Immunogen

Recombinant protein within human munc13-4 aa 900-1090.

Host

Rabbit

Positive Control

Jurkat cell lysate, K562 cell lysate, rat lung tissue lysate, Hela, SHSY5Y, rat spleen tissue, human placenta tissue.

Conjugation

Unconjugated

Clonality

Polyclonal

RRID

AB_3071152

APPLICATION DILUTION

  • WB

  • 1:500-1:2,000

  • IF-Cell

  • 1:50-1:200

  • IHC-P

  • 1:50-1:200

PROPERTIES

Form

Liquid

Storage Condition

Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.

Storage Buffer

1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Immunogen affinity purified.

Molecular Weight

123 kDa

Isotype

IgG

TARGET

UNIPROT #

Q70J99

PROTEIN NAME

Munc13-4

SYNONYMS

FHL 3 antibody;FHL3 antibody;FLJ00067 antibody;HLH 3 antibody;HLH3 antibody;HPLH 3 antibody;HPLH3 antibody;Jinx antibody;Munc13 4 antibody;Munc13-4 antibody;Protein unc 13 homolog D antibody;Protein unc-13 homolog D antibody;UN13D_HUMAN antibody;Unc 13 homolog D antibody;UNC 13D antibody;Unc-13 homolog D (C. elegans) antibody;Unc13 homolog D (C elegans) antibody;Unc13 homolog D antibody;UNC13, C. elegans, homolog of, D antibody;UNC13D antibody;Unc13h4 antibody

SUBCELLULAR LOCATION

Cytoplasm, Endosome, Lysosome, Membrane.

FUNCTION

Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Regulates assembly of recycling and late endosomal structures, leading to the formation of an endosomal exocytic compartment that fuses with perforin-containing granules at the immunologic synapse and licences them for exocytosis. Regulates Ca2+-dependent secretory lysosome exocytosis in mast cells.Expressed at high levels in spleen, thymus and leukocytes. Also expressed in lung and placenta, and at very low levels in brain, heart, skeletal muscle and kidney. Expressed in cytotoxic T-lymphocytes (CTL) and mast cells.

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