MuERVL-Gag Rabbit Polyclonal Antibody (ER50102)
Catalog# ER50102
Rabbit Polyclonal to MuERVL-Gag
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IF-Cell
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WB
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Mouse
Specifications
Product Type
Rabbit polyclonal primary
Product Name
MuERVL-Gag Rabbit Polyclonal Antibody (ER50102)
Immunogen
Synthetic peptide within mouse muervl-gag aa 541-581/581.
Host
Rabbit
Positive Control
Mouse embryo, ES-D3 cell lysate, ES-W4 cell lysate.
Conjugation
Unconjugated
Clonality
Polyclonal
RRID
APPLICATION DILUTION
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IF-Cell
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1:200
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WB
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1:1,000-1:5,000
PROPERTIES
Form
Liquid
Storage Condition
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1ug/ul
Purification
Immunogen affinity purified.
Molecular Weight
Predicted band size: 67 kDa
Isotype
IgG
TARGET
UNIPROT #
PROTEIN NAME
MuERVL-Gag
FUNCTION
A large number of retrotransposons are expressed when the zygotic genome is first transcribed, including the endogenous retroviruses (ERVs), LINE-1 elements, and the non-autonomous SINE elements. At the 2C stage, MuERV-L/MERVL retrovirus-like elements are transiently de-repressed and produce 3% of the transcribed mRNAs. Following the 2C stage, MERVL-retroelement expression is silenced. The newly study discovered that this regulated pattern of MERVL expression overlapped with greater than one hundred 2C-specific genes that have co-opted regulatory elements from these foreign retroviruses to initiate their transcription.
CITATIONS
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Sina Atashpaz; Vincenzo Costanzo
ATR expands embryonic stem cell fate potential in response to replication stress
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WB
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IHC
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Mouse
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Citation
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Shunze Jia,et al
The pluripotent-to-totipotent state transition in mESCs activates the intrinsic apoptotic pathway through DUX-induced DNA replication stress
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IF
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mice
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Citation
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Puri, D., Koschorz, B., Engist, B., Onishi-Seebacher, M., Ryan, D., Soujanya, M., & Montavon, T.
Foxd3 controls heterochromatin‐mediated repression of repeat elements and 2‐cell state transcription
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IF
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Mouse
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Citation
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Jamie A Hackett, M Azim Surani
Stella modulates transcriptional and endogenous retrovirus programs during maternal-to-zygotic transition
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IF
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Mouse
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Citation
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Kubinyecz, O., Santos, F., Drage, D., Reik, W., & Eckersley-Maslin, M. A.
Maternal Dppa2 and Dppa4 are dispensable for zygotic genome activation but important for offspring survival
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IF
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Mouse
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Citation
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A genome-wide screen reveals new regulators of the 2-cell-like cell state
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IF
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Mouse
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Citation
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Yang Jian,et al
Systematic evaluation of retroviral LTRs as cis-regulatory elements in mouse embryos
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IF
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Mouse
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Citation
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