Phospho-mTOR (S2448) Mouse Monoclonal Antibody [A5D5] (HA600094)

UNIPROT #

P42345

PROTEIN NAME

Phospho-mTOR (S2448)

SYNONYMS

dJ576K7.1 (FK506 binding protein 12 rapamycin associated protein 1) antibody;FK506 binding protein 12 rapamycin associated protein 1 antibody;FK506 binding protein 12 rapamycin associated protein 2 antibody;FK506 binding protein 12 rapamycin complex associated protein 1 antibody;FK506-binding protein 12-rapamycin complex-associated protein 1 antibody;FKBP rapamycin associated protein antibody;FKBP12 rapamycin complex associated protein antibody;FKBP12-rapamycin complex-associated protein 1 antibody;FKBP12-rapamycin complex-associated protein antibody;FLJ44809 antibody;FRAP antibody;FRAP1 antibody;FRAP2 antibody;Mammalian target of rapamycin antibody;Mechanistic target of rapamycin antibody;mTOR antibody;MTOR_HUMAN antibody;OTTHUMP00000001983 antibody;RAFT1 antibody;Rapamycin and FKBP12 target 1 antibody;Rapamycin associated protein FRAP2 antibody;Rapamycin target protein 1 antibody;Rapamycin target protein antibody;RAPT1 antibody;Serine/threonine-protein kinase mTOR antibody

SUBCELLULAR LOCATION

Lysosome, Mitochondrion outer membrane, Endoplasmic reticulum membrane, Cytoplasm.

FUNCTION

The phosphatidylinositol kinase (PIK) family members fall into two distinct subgroups. The first subgroup contains proteins such as the PI 3- and PI 4-kinases and the second group comprises the PIK-related kinases. The PIK-related kinases include Atm, DNA-PKCS and FRAP. These proteins have in common a region of homology at their carboxy-termini that is not present in the PI 3- and PI 4-kinases. The Atm gene is mutated in the autosomal recessive disorder ataxia telangiectasia (AT) that is characterized by cerebellar degeneration (ataxia) and the appearance of dilated blood vessels (telangiectases) in the conjunctivae of the eyes. AT cells are hypersensitive to ionizing radiation, impaired in mediating the inhibition of DNA synthesis and display delays in p53 induction. DNA-PK is a heterotrimeric DNA binding enzyme that is composed of a large subunit, DNA-PKCS, and two smaller subunits collectively known as Ku. The loss of DNA-PK leads to defects in DSB repair and V(D)J recombination. FRAP can autophosphorylate on serine and bind to Rapamycin/FKBP. FRAP is also an upstream regulator of S6 kinase and has been implicated in the regulation of p27 and p21 expression.