MTHFD2 Rabbit Polyclonal Antibody (ER1902-98)
Catalog# ER1902-98
Rabbit Polyclonal to MTHFD2
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WB
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IHC-P
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FC
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Human
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Mouse
Positive control:
Lane 1: HL-60 cell lysate
Lane 2: 293T cell lysate
Specifications
Product Type
Rabbit polyclonal primary
Product Name
MTHFD2 Rabbit Polyclonal Antibody (ER1902-98)
Immunogen
Synthetic peptide within human mthfd2 aa 210-250.
Host
Rabbit
Positive Control
HL-60 cell lysate, 293T cell lysate, human colon carcinoma tissue, mouse kidney tissue, human tonsil carcinoma tissue, Daudi.
Conjugation
Unconjugated
Clonality
Polyclonal
RRID
APPLICATION DILUTION
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WB:1:500-1:2,000
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IHC-P:1:50-1:200
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FC:1:50-1:100
PROPERTIES
Form
Liquid
Storage Condition
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.
Storage Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1ug/ul
Purification
Immunogen affinity purified.
Molecular Weight
38 kDa
Isotype
IgG
TARGET
UNIPROT #
PROTEIN NAME
MTHFD2
SYNONYMS
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial antibody;Descriptions antibody;Methenyltetrahydrofolate cyclohydrolase antibody;methylene tetrahydrofolate dehydrogenase (NAD+ dependent) antibody;methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 antibody;methylenetetrahydrofolate dehydrogenase (NADP+ dependent) antibody;methylenetetrahydrofolate dehydrogenase 2 antibody;MGC82516 antibody;MTDC_HUMAN antibody;MTHFD2 antibody;mthfd2 methylene tetrahydrofolate dehydrogenase (NAD+ dependent) antibody;NAD-dependent methylene tetrahydrofolate dehydrogenase antibody;NAD-dependent methylenetetrahydrofolate dehydrogenase antibody;NMDMC antibody
SUBCELLULAR LOCATION
Mitochondrion.
FUNCTION
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial is an enzyme that in humans is encoded by the MTHFD2 gene. This gene encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD. Alternative splicing results in two different transcripts, one protein-coding and the other not protein-coding. This gene has a pseudogene on chromosome 7.
CITATIONS
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ROS-responsive fluorinated polyethyleneimine vector to co-deliver shMTHFD2 and shGPX4 plasmids induces ferroptosis and apoptosis for cancer therapy
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WB
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Mouse
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Citation
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