MSI2 Rabbit Polyclonal Antibody (ER1706-59)

UNIPROT #

Q96DH6

PROTEIN NAME

MSI2

SYNONYMS

FLJ36569 antibody;MGC3245 antibody;Msi2 antibody;MSI2/HOXA9 fusion gene, included antibody;MSI2H antibody;MSI2H_HUMAN antibody;Musashi 2 antibody;Musashi homolog 2 antibody;Musashi RNA binding protein 2 antibody;Musashi, Drosophila, homolog of, 2 antibody;Musashi-2 antibody;RNA binding protein Musashi homolog 2 antibody;RNA-binding protein Musashi homolog 2 antibody;WD 40 repeat protein MSI2 antibody

SEQUENCE SIMILARITIES

Belongs to the Musashi family.

TISSUE SPECIFICITY

Ubiquitous; detected at low levels.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated.

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

Msi2 (musashi homolog 2), also known as MSI2H, is a 328 amino acid protein that localizes to the cytoplasm and contains two RRM (RNA recognition motif) domains. Expressed ubiquitously at low levels, Msi2 functions as an RNA binding protein that, by regulating the expression of target mRNAs, is thought to play a role in the proliferation and maintenance of stem cells within the central nervous system. Msi2 is subject to post-translational phosphorylation and is upregulated in response to brain injury, suggesting a role in healing and brain tissue regeneration. Chromosomal aberrations involving the Msi2 gene are associated with the progression of chronic myeloid leukemia. Multiple isoforms of Msi2 exist due to alternative splicing events.