MSH6 Rabbit Polyclonal Antibody (ER30902)

UNIPROT #

P52701

PROTEIN NAME

MSH6

SYNONYMS

DNA mismatch repair protein Msh6 antibody;G/T mismatch binding protein antibody;G/T mismatch-binding protein antibody;GTBP antibody;GTMBP antibody;hMSH6 antibody;HNPCC 5 antibody;HNPCC5 antibody;HSAP antibody;MSH 6 antibody;MSH6 antibody;MSH6_HUMAN antibody;mutS (E. coli) homolog 6 antibody;MutS alpha 160 kDa subunit antibody;MutS homolog 6 (E. coli) antibody;mutS homolog 6 antibody;MutS-alpha 160 kDa subunit antibody;p160 antibody;Sperm associated protein antibody

SEQUENCE SIMILARITIES

Belongs to the DNA mismatch repair MutS family.

POST-TRANSLATIONAL MODIFICATION

The N-terminus is blocked.; Phosphorylated by PRKCZ, which may prevent MutS alpha degradation by the ubiquitin-proteasome pathway.

SUBCELLULAR LOCATION

Nucleus, chromosome.

FUNCTION

The DNA mismatch repair system (MMR) repairs post-replication DNA, inhibits recombination between nonidentical DNA sequences, and induces both checkpoint and apoptotic responses following certain types of DNA damage. MSH6 heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. Mutations in MSH6 and other MMR proteins have been found in a large proportion of hereditary nonpolyposis colorectal cancer (Lynch Syndrome), the most common form of inherited colorectal cancer in the Western world.