MSH6 Mouse Monoclonal Antibody [A4C4] (EM1902-24)

UNIPROT #

P52701

PROTEIN NAME

MSH6

SYNONYMS

DNA mismatch repair protein Msh6 antibody;G/T mismatch binding protein antibody;G/T mismatch-binding protein antibody;GTBP antibody;GTMBP antibody;hMSH6 antibody;HNPCC 5 antibody;HNPCC5 antibody;HSAP antibody;MSH 6 antibody;MSH6 antibody;MSH6_HUMAN antibody;mutS (E. coli) homolog 6 antibody;MutS alpha 160 kDa subunit antibody;MutS homolog 6 (E. coli) antibody;mutS homolog 6 antibody;MutS-alpha 160 kDa subunit antibody;p160 antibody;Sperm associated protein antibody

SEQUENCE SIMILARITIES

Belongs to the DNA mismatch repair MutS family.

POST-TRANSLATIONAL MODIFICATION

The N-terminus is blocked.; Phosphorylated by PRKCZ, which may prevent MutS alpha degradation by the ubiquitin-proteasome pathway.

SUBCELLULAR LOCATION

Nucleus, Chromosome.

FUNCTION

This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described.