MRPS15 Recombinant Rabbit Monoclonal Antibody [JE62-21] (HA720106)

UNIPROT #

P82914

PROTEIN NAME

MRPS15

SYNONYMS

28S ribosomal protein S15 antibody;28S ribosomal protein S15, mitochondrial [Precursor] antibody;DC37 antibody;FLJ11564 antibody;mitochondrial antibody;mitochondrial ribosomal protein S15 antibody;MPR S15 antibody;MRP-S15 antibody;MRPS15 antibody;RPMS15 antibody;RT15_HUMAN antibody;S15mt antibody

SUBCELLULAR LOCATION

Mitochondrion.

FUNCTION

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S15P family. The encoded protein is more than two times the size of its E. coli counterpart, with the 12S rRNA binding sites conserved. Between human and mouse, the encoded protein is the least conserved among small subunit ribosomal proteins. Pseudogenes corresponding to this gene are found on chromosomes 15q and 19q.