TPOR / MPL Rabbit Polyclonal Antibody (HA500360)

UNIPROT #

P40238

PROTEIN NAME

MPL

SYNONYMS

C MPL antibody;CD110 antibody;mpl antibody;MPLV antibody;Myeloproliferative leukemia protein antibody;Myeloproliferative leukemia virus oncogene antibody;Proto-oncogene c-Mpl antibody;THCYT2 antibody;Thrombopoietin receptor antibody;TPO R antibody;TPO-R antibody;TPOR antibody;TPOR_HUMAN antibody

SUBCELLULAR LOCATION

Cell membrane, Golgi apparatus, Cell surface.

FUNCTION

The thrombopoietin receptor also known as the myeloproliferative leukemia protein or CD110 (Cluster of Differentiation 110) is a protein that in humans is encoded by the MPL (myeloproliferative leukemia virus) oncogene. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin, CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated.