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Mouse TREM2, C-Strep II Tag (ECD) Protein (HA210924)

Price: Regular price $389.00

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Catalog# HA210924

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  • Mouse

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Product Details

Product Type

Protein

Product Name

Mouse TREM2, C-Strep II Tag (ECD) Protein (HA210924)

Predicted molecular mass

18.5 kD

Protein construction description

A DNA sequence encoding the mouse TREM2 protein (Q99NH8-1) (Leu 19-Ser 171) was expressed with a Strep II tag at the C-terminus

Accession

Q99NH8-1

Protein construction

TREM2 (19-171) | Strep II

Source

HEK293

Bio Activity

Testing in progress.

Purity

>95% as determined by SDS-PAGE.

Endotoxin

Less than 1.0 EU per μg by the LAL method.

Formulation

Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.

Species

Mouse

Background

Triggering receptor expressed on myeloid cells 2 (TREM2) is a protein that in humans is encoded by the TREM2 gene. TREM2 is expressed on macrophages, immature monocyte-derived dendritic cells, osteoclasts, and microglia, which are immune cells in the central nervous system. In the liver, TREM2 is expressed by several cell types, including macrophages, that respond to injury. In the intestine, TREM2 is expressed by myeloid-derived dendritic cells and macrophage. TREM2 is overexpressed in many tumor types and has anti-inflammatory activities. It might therefore be a good therapeutic target.

Usage Guide

Shipping

In general, recombinant proteins are provided as lyophilized powder which are shipped with blue ice. Bulk packages of recombinant proteins are provided as frozen liquid which are shipped with dry ice.

Storage

Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20C to -80C It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.

Reconstitution

Reconstitute at 250 μg/ml in sterile water.

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