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Mouse IL-21 Recombinant Rabbit Monoclonal Antibody - BSA and Azide free (Detector) [PSH04-75] (HA722175)

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Catalog# HA722175

Rabbit Monoclonal to Mouse IL-21

Tested for

  • ELISA(Det)

Reacts with

  • Mouse

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free

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Specifications

Product Type

Recombinant Rabbit monoclonal primary

Product Name

Mouse IL-21 Recombinant Rabbit Monoclonal Antibody - BSA and Azide free (Detector) [PSH04-75] (HA722175)

Immunogen

Recombinant protein within mouse il-21 aa 18-146 (q9es17).

Host

Rabbit

Positive Control

Recombinant Mouse IL-21 protein (HA210801).

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

PSH04-75

APPLICATION DILUTION

  • ELISA(Det)

  • Use at an assay dependent concentration. Can be paired for Sandwich ELISA with Rabbit monoclonal [PSH04-74] to Mouse IL-21 antibody (Capture) (HA722174) and recombinant Mouse IL-21 protein as the standard (HA210801). The reference range value is 20.6-2,000 pg/ml.

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.

Storage Buffer

PBS (pH7.4).

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 17 kDa

Isotype

IgG

TARGET

UNIPROT #

Q9ES17

PROTEIN NAME

Mouse IL-21

SYNONYMS

CVID11 antibody;IL 21 antibody;IL-21 antibody;Il21 antibody;IL21_HUMAN antibody;Interleukin 21 antibody;Interleukin-21 antibody;interleukin-21 isoform antibody;Interleukin21 antibody;OTTHUMP00000164088 antibody;Za11 antibody

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Interleukin 21 (IL-21) is a protein that in humans is encoded by the IL21 gene. Interleukin-21 is a cytokine that has potent regulatory effects on cells of the immune system, including natural killer (NK) cells and cytotoxic T cells that can destroy virally infected or cancerous cells. This cytokine induces cell division/proliferation in its target cells. The IL-21 receptor (IL-21R) is expressed on the surface of T, B and NK cells. IL-21r is similar in structure to the receptors for other type I cytokines like IL-2R or IL-15 and requires dimerization with the common gamma chain (γc) in order to bind IL-21. When bound to IL-21, the IL-21 receptor acts through the Jak/STAT pathway, utilizing Jak1 and Jak3 and a STAT3 homodimer to activate its target genes.

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