Mouse CD8 alpha Recombinant Rat Monoclonal Antibody [PSH16-78] (HA601543)

UNIPROT #

P01731

PROTEIN NAME

Mouse CD8 alpha

SYNONYMS

alpha polypeptide (p32) antibody;CD_antigen=CD8a antibody;CD8 antibody;CD8 antigen alpha polypeptide antibody;CD8 antigen alpha polypeptide (p32) antibody;CD8 antigen, alpha polypeptide (p32) antibody;CD8a antibody;CD8A antigen antibody;CD8A molecule antibody;CD8A_HUMAN antibody;Leu2 antibody;Leu2 T lymphocyte antigen antibody;Ly 2 antibody;Ly 35 antibody;Ly B antibody;Ly2 antibody;Ly3 antibody;Ly35 antibody;LyB antibody;Lyt 2.1 lymphocyte differentiation antigen (AA at 100) antibody;LYT3 antibody;MAL antibody;OKT8 T cell antigen antibody;OTTHUMP00000160760 antibody;OTTHUMP00000160764 antibody;OTTHUMP00000203528 antibody;OTTHUMP00000203721 antibody;p32 antibody;T cell antigen Leu2 antibody;T cell co receptor antibody;T lymphocyte differentiation antigen T8/Leu 2 antibody;T-cell surface glycoprotein CD8 alpha chain antibody;T-cell surface glycoprotein Lyt 2 antibody;T-lymphocyte differentiation antigen T8/Leu-2 antibody;T8 T cell antigen antibody;T8/Leu-2 T-lymphocyte differentiation antigen antibody

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

CD8 is a pivotal integral membrane glycoprotein that is crucial for immune responses. In T-cells, CD8 primarily acts as a coreceptor for the MHC class I molecule:peptide complex. It simultaneously interacts with the T-cell receptor (TCR) and MHC class I proteins presented by antigen-presenting cells (APCs). This interaction recruits the Src kinase LCK to the TCR-CD3 complex, initiating intracellular signaling pathways. These pathways lead to lymphokine production, motility, adhesion, and activation of cytotoxic T-lymphocytes (CTLs), enabling CTLs to recognize and eliminate infected and tumor cells. In NK-cells, CD8A homodimers on the cell surface provide a survival mechanism. They facilitate conjugation and lysis of multiple target cells and promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells. Overall, CD8 is indispensable in both T-cell mediated cellular immunity and NK-cell mediated natural immunity, offering strong protection against pathogens and internal anomalies.