MMP-9 Mouse Monoclonal Antibody [10A1] (EM1801-22)

UNIPROT #

P14780

PROTEIN NAME

MMP-9

SYNONYMS

82 kDa matrix metalloproteinase-9 antibody;92 kDa gelatinase antibody;92 kDa type IV collagenase antibody;CLG 4B antibody;CLG4B antibody;Collagenase Type 4 beta antibody;Collagenase type IV 92 KD antibody;EC 3.4.24.35 antibody;Gelatinase 92 KD antibody;Gelatinase B antibody;Gelatinase beta antibody;GelatinaseB antibody;GELB antibody;Macrophage gelatinase antibody;MANDP2 antibody;Matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) antibody;Matrix Metalloproteinase 9 antibody;MMP 9 antibody;MMP-9 antibody;MMP9 antibody;MMP9_HUMAN antibody;Type V collagenase antibody

SEQUENCE SIMILARITIES

Belongs to the peptidase M10A family.

TISSUE SPECIFICITY

Detected in neutrophils (at protein level). Produced by normal alveolar macrophages and granulocytes.

POST-TRANSLATIONAL MODIFICATION

Processing of the precursor yields different active forms of 64, 67 and 82 kDa. Sequentially processing by MMP3 yields the 82 kDa matrix metalloproteinase-9.; N- and O-glycosylated.

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Matrix metallopeptidase 9 (MMP-9), also known as 92 kDa type IV collagenase, 92 kDa gelatinase or gelatinase B (GELB), is a matrixin, a class of enzymes that belong to the zinc-metalloproteinases family involved in the degradation of the extracellular matrix. In humans the MMP9 gene encodes for a signal peptide, a propeptide, a catalytic domain with inserted three repeats of fibronectin type II domain followed by a C-terminal hemopexin-like domain.MMP9, along with elastase, appears to be a regulatory factor in neutrophil migration across the basement membrane.MMP9 plays several important functions within neutrophil action, such as degrading extracellular matrix, activation of IL-1β, and cleavage of several chemokines. In a mouse model, MMP9 deficiency resulted in resistance to endotoxin shock, suggesting that MMP9 is important in sepsis.