Lane 1: human liver tissue lysate
Lane 2: rat liver tissue lysate
Recombinant Rabbit monoclonal primary
MMP3 Recombinant Rabbit Monoclonal Antibody [JM46-22] (ET1705-98)
Human liver tissue lysate, rat liver tissue lysate, rat kidney tissue, human liver tissue, human placenta tissue, mouse liver tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
CHDS6 antibody; Matrix metalloproteinase 3 antibody; Matrix metalloproteinase-3 antibody; MGC126102 antibody; MGC126103 antibody; MGC126104 antibody; MMP 3 antibody; MMP-3 antibody; MMP3 antibody; MMP3_HUMAN antibody; Proteoglycanase antibody; SL-1 antibody; SL1 antibody; STMY antibody; STMY1 antibody; STR1 antibody; Stromelysin 1 antibody; Stromelysin-1 antibody; Transin 1 antibody; Transin-1 antibody
Belongs to the peptidase M10A family.
The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-3, MMP-10 and MMP-11 (also designated stromelysin-1, -2 and -3 respectively) activate procollagenase. MMP-3 activation of procollagenase can occur via two pathways. Direct activation by MMP-3 is slow and activation by MMP-3 in conjunction with tissue or plasma proteinases is rapid. MMP-10 is expressed in small intestine, and at lower levels in lung and heart. MMP-11 is specifically expressed in stromal cells of breast carcinomas and contributes to epithelial cell malignancies.