MMP3 Recombinant Rabbit Monoclonal Antibody [JM46-22] (ET1705-98)
Catalog# ET1705-98
Rabbit Monoclonal to MMP3
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WB
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IHC-P
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Human
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Mouse
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Rat
Positive control:
Lane 1: human liver tissue lysate
Lane 2: rat liver tissue lysate
Specifications
Product Type
Recombinant Rabbit monoclonal primary
Product Name
MMP3 Recombinant Rabbit Monoclonal Antibody [JM46-22] (ET1705-98)
Immunogen
Synthetic peptide within c-terminal human mmp3.
Host
Rabbit
Positive Control
Human liver tissue lysate, rat liver tissue lysate, rat kidney tissue, human liver tissue, human placenta tissue, mouse liver tissue.
Conjugation
Unconjugated
Clonality
Monoclonal
Clone Number
JM46-22
APPLICATION DILUTION
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WB
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1:500-1:2,000
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IHC-P
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1:50-1:200
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1ug/ul
Purification
Protein A affinity purified.
Molecular Weight
Predicted band size: 54 kDa
Isotype
IgG
TARGET
UNIPROT #
PROTEIN NAME
MMP3
SYNONYMS
CHDS6 antibody;Matrix metalloproteinase 3 antibody;Matrix metalloproteinase-3 antibody;MGC126102 antibody;MGC126103 antibody;MGC126104 antibody;MMP 3 antibody;MMP-3 antibody;MMP3 antibody;MMP3_HUMAN antibody;Proteoglycanase antibody;SL-1 antibody;SL1 antibody;STMY antibody;STMY1 antibody;STR1 antibody;Stromelysin 1 antibody;Stromelysin-1 antibody;Transin 1 antibody;Transin-1 antibody
SEQUENCE SIMILARITIES
Belongs to the peptidase M10A family.
SUBCELLULAR LOCATION
extracellular matrix.
FUNCTION
The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-3, MMP-10 and MMP-11 (also designated stromelysin-1, -2 and -3 respectively) activate procollagenase. MMP-3 activation of procollagenase can occur via two pathways. Direct activation by MMP-3 is slow and activation by MMP-3 in conjunction with tissue or plasma proteinases is rapid. MMP-10 is expressed in small intestine, and at lower levels in lung and heart. MMP-11 is specifically expressed in stromal cells of breast carcinomas and contributes to epithelial cell malignancies.
CITATIONS
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Luo, P., Yan, H., Chen, X., Zhang, Y., Zhao, Z., Cao, J., Zhu, Y., Du, J., Xu, Z., Zhang, X., Zeng, S., Yang, B., Ma, S., & He, Q.
s-HBEGF/SIRT1 circuit-dictated crosstalk between vascular endothelial cells and keratinocytes mediates sorafenib-induced hand-foot skin reaction that can be reversed by nicotinamide. Cell research, 30(9), 779–793.
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WB
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IF
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IHC
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Human
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Citation
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