MMP-2 Recombinant Rabbit Monoclonal Antibody [SI15-04] (ET1606-4)

UNIPROT #

P08253

PROTEIN NAME

MMP-2

SYNONYMS

72 kDa gelatinase antibody;72kD type IV collagenase antibody;CLG 4 antibody;CLG 4A antibody;CLG4 antibody;CLG4A antibody;Collagenase Type 4 alpha antibody;Collagenase type IV A antibody;Gelatinase A antibody;Gelatinase alpha antibody;Gelatinase neutrophil antibody;Matrix metallopeptidase 2 gelatinase A 72kDa gelatinase 72kDa type IV collagenase antibody;Matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) antibody;Matrix Metalloproteinase 2 antibody;Matrix metalloproteinase II antibody;Matrix metalloproteinase-2 antibody;MMP 2 antibody;MMP II antibody;MMP-2 antibody;MMP2 antibody;MMP2_HUMAN antibody;MONA antibody;Neutrophil gelatinase antibody;PEX antibody;TBE 1 antibody;TBE-1 antibody

SEQUENCE SIMILARITIES

Belongs to the peptidase M10A family.

TISSUE SPECIFICITY

Produced by normal skin fibroblasts. PEX is expressed in a number of tumors including gliomas, breast and prostate.

POST-TRANSLATIONAL MODIFICATION

Phosphorylation on multiple sites modulates enzymatic activity. Phosphorylated by PKC in vitro.; The propeptide is processed by MMP14 (MT-MMP1) and MMP16 (MT-MMP3). Autocatalytic cleavage in the C-terminal produces the anti-angiogenic peptide, PEX. This processing appears to be facilitated by binding integrinv/beta3.

SUBCELLULAR LOCATION

Cytoplasm, Nucleus, Membrane, Mitochondrion, Secreted.

FUNCTION

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix (ECM) in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Activation of MMP-2 requires proteolytic processing. A complex of membrane type 1 MMP (MT1-MMP/MMP14) and tissue inhibitor of metalloproteinase 2 recruits pro-MMP 2 from the extracellular milieu to the cell surface. Activation then requires an active molecule of MT1-MMP and auto catalytic cleavage. Clustering of integrin chains promotes activation of MMP-2. Another factor that will support the activation of MMP-2 is cell-cell clustering. A wild-type activated leukocyte cell adhesion molecule (ALCAM) is also required to activate MMP-2.