MMP-17 Recombinant Rabbit Monoclonal Antibody [JU33-03] (ET7106-84)

UNIPROT #

Q9ULZ9

PROTEIN NAME

MMP-17

SYNONYMS

Matrix metalloproteinase 17 antibody;Matrix metalloproteinase 17 membrane inserted antibody;Matrix metalloproteinase-17 antibody;Membrane type 4 matrix metalloproteinase antibody;Membrane type matrix metalloproteinase 4 antibody;Membrane-type matrix metalloproteinase 4 antibody;Membrane-type-4 matrix metalloproteinase antibody;MMP 17 antibody;MMP-17 antibody;Mmp17 antibody;MMP17_HUMAN antibody;MT MMP 4 antibody;MT MMP4 antibody;MT-MMP 4 antibody;MT4 MMP antibody;MT4-MMP antibody;MT4MMP antibody;MTMMP 4 antibody;MTMMP4 antibody

SEQUENCE SIMILARITIES

Belongs to the peptidase M10A family.

TISSUE SPECIFICITY

Expressed in brain, leukocytes, colon, ovary testis and breast cancer. Expressed also in many transformed and non-transformed cell types.

POST-TRANSLATIONAL MODIFICATION

The precursor is cleaved by a furin endopeptidase.

SUBCELLULAR LOCATION

Secreted. Plasma membrane.

FUNCTION

Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Cleaves pro-TNF-alpha at the '74-Ala-|-Gln-75' site. Not obvious if able to proteolytically activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin.