MMP-13 Recombinant Rabbit Monoclonal Antibody [JF0893] (ET1702-14)

UNIPROT #

P45452

PROTEIN NAME

MMP-13

SYNONYMS

CLG 3 antibody;CLG3 antibody;Collagenase 3 antibody;Collagenase3 antibody;MANDP1 antibody;Matrix metallopeptidase 13 (collagenase 3) antibody;Matrix Metalloproteinase 13 antibody;Matrix metalloproteinase-13 antibody;MMP 13 antibody;MMP-13 antibody;Mmp13 antibody;MMP13_HUMAN antibody

SEQUENCE SIMILARITIES

Belongs to the peptidase M10A family.

TISSUE SPECIFICITY

Detected in fetal cartilage and calvaria, in chondrocytes of hypertrophic cartilage in vertebrae and in the dorsal end of ribs undergoing ossification, as well as in osteoblasts and periosteal cells below the inner periosteal region of ossified ribs. Detected in chondrocytes from in joint cartilage that have been treated with TNF and IL1B, but not in untreated chondrocytes. Detected in T lymphocytes. Detected in breast carcinoma tissue.

POST-TRANSLATIONAL MODIFICATION

The proenzyme is activated by removal of the propeptide; this cleavage can be effected by other matrix metalloproteinases, such as MMP2, MMP3 and MMP14 and may involve several cleavage steps. Cleavage can also be autocatalytic, after partial maturation by another protease or after treatment with 4-aminophenylmercuric acetate (APMA) (in vitro).; N-glycosylated.; Tyrosine phosphorylated by PKDCC/VLK.

SUBCELLULAR LOCATION

Extracellular matrix, Secreted.

FUNCTION

The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-13 (also designated collagenase-3) is produced by breast carcinomas and degrades collagen types I, II and III. MMP-13 has wide substrate specificity, and its physiologic expression is limited to situations in which rapid and effective remodeling of collagenous ECM takes place, such as fetal bone development and adult bone remodeling.