Rabbit polyclonal primary
MMP-3 Rabbit Polyclonal Antibody (ER1706-77)
Recombinant protein within c-terminal human mmp-3.
A549, LOVO, rat brain tissue, human tonsil tissue, human liver tissue, human colon cancer tissue, mouse brain tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Peptide affinity purified
CHDS6 antibody; Matrix metalloproteinase 3 antibody; Matrix metalloproteinase-3 antibody; MGC126102 antibody; MGC126103 antibody; MGC126104 antibody; MMP 3 antibody; MMP-3 antibody; MMP3 antibody; MMP3_HUMAN antibody; Proteoglycanase antibody; SL-1 antibody; SL1 antibody; STMY antibody; STMY1 antibody; STR1 antibody; Stromelysin 1 antibody; Stromelysin-1 antibody; Transin 1 antibody; Transin-1 antibody
Belongs to the peptidase M10A family.
Extracellular matrix. Secreted.
The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-3, MMP-10 and MMP-11 (also designated stromelysin-1, -2 and -3 respectively) activate procollagenase. MMP-3 activation of procollagenase can occur via two pathways. Direct activation by MMP-3 is slow and activation by MMP-3 in conjunction with tissue or plasma proteinases is rapid. MMP-10 is expressed in small intestine, and at lower levels in lung and heart. MMP-11 is specifically expressed in stromal cells of breast carcinomas and contributes to epithelial cell malignancies.