Lane 1: HT29
Lane 2: HUVEC
Lane 3: Hela
Recombinant Rabbit monoclonal primary
MLKL Recombinant Rabbit Monoclonal Antibody [SA40-04] (ET1601-25)
HUVEC, HT29, Hela, HepG2, human tonsil tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
9130019I15Rik antibody; FLJ34389 antibody; hMLKL antibody; Mixed lineage kinase domain like antibody; Mixed lineage kinase domain like protein antibody; Mixed lineage kinase domain-like protein antibody; Mlkl antibody; MLKL_HUMAN antibody
Belongs to the protein kinase superfamily.
Phosphorylation by RIPK3 induces a conformational switch that is required for necroptosis. It also induces homotrimerization and localization to the plasma membrane.
Cytoplasm, Cell membrane, Golgi apparatus.
MLKL (mixed lineage kinase domain-like) is a 471 amino acid protein that contains one protein kinase domain which is thought to be catalytically inactive. The gene encoding MLKL maps to chromosome 16 and is expressed as two isoforms which are produced by alternative splicing events. Chromosome 16, which is associated with a variety of genetic disorders, encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition.