MINA53 Recombinant Rabbit Monoclonal Antibody [JA11-63] (ET1704-07)

UNIPROT #

Q8IUF8

PROTEIN NAME

MINA53

SYNONYMS

60S ribosomal protein L27a histidine hydroxylase antibody;Bifunctional lysine specific demethylase and histidyl hydroxylase MINA antibody;FLJ14393 antibody;Histone lysine demethylase MINA antibody;MDIG antibody;MINA antibody;MINA_HUMAN antibody;Mineral dust-induced gene protein antibody;Myc induced nuclear antigen 53 kDa antibody;MYC induced nuclear antigen antibody;MYC-induced nuclear antigen antibody;NO52 antibody;Nucleolar protein 52 antibody;Ribosomal oxygenase MINA antibody;ROX antibody

SEQUENCE SIMILARITIES

Belongs to the ROX family. MINA53 subfamily.

TISSUE SPECIFICITY

Expressed in liver, skeletal muscle, heart, pancreas, and placenta. Not detected in brain, lung or kidney. Expressed in several lung cancer tissues, but is barely detected in the adjacent non-cancerous tissues. Also highly expressed in several esophageal squamous cell carcinoma (ESCC), and colon cancer tissues, and in various cancer cell lines.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles.