Line 1: Mouse brain
Line 2: Jurkat
Line 3: Hela
Recombinant Rabbit monoclonal primary
MIF Recombinant Rabbit Monoclonal Antibody [JM11-64] (ET1703-89)
Jurkat, Hela, THP-1, mouse brain.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
GIF antibody; GLIF antibody; Glycosylation inhibiting factor antibody; Glycosylation-inhibiting factor antibody; L-dopachrome isomerase antibody; L-dopachrome tautomerase antibody; Macrophage migration inhibitory factor (glycosylation-inhibiting factor) antibody; Macrophage migration inhibitory factor antibody; MIF antibody; MIF protein antibody; MIF_HUMAN antibody; MMIF antibody; Phenylpyruvate tautomerase antibody
Belongs to the MIF family.
Macrophage migration inhibitory factor, known as MIF or glycosylation-inhibiting factor, is a secreted, homotrimeric, pro-inflammatory cytokine that modulates macrophage and T cell function and is an important regulator of host response to infection. MIF is expressed at sites of inflammation, which suggests that it plays a role in regulating macrophage function in host defense. MIF is produced by the pituitary gland and is found in monocytes, macrophages, differentiating immunological cells in the eye lens and brain, and fibroblasts. Elevated levels of MIF protein are detected in the plasma of patients with severe sepsis or septic shock, a condition where MIF influences endotoxic shock by enhancing the production of other inflammatory cytokines including tumor necrosis factor α (TNFα), interleukin-1 (IL-1) and interferon-γ (IFN-γ). MIF promotes the systemic inflammatory response by counter-regulating glucocorticoid-mediated inhibition of immune-cell activation and proinflammatory cytokine production. MIF may mediate tissue destruction through the induction of proteinases.