Recombinant Rabbit monoclonal primary
Midkine Recombinant Rabbit Monoclonal Antibody [JF096-5] (ET1702-64)
Synthetic peptide within c-terminal human midkine.
Human liver cancer tissue, human pancreas tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
Amphiregulin associated protein antibody; Amphiregulin-associated protein antibody; ARAP antibody; FLJ27379 antibody; Mdk antibody; Midgestation and kidney protein antibody; Midkine antibody; MK 1 antibody; MK antibody; MK_HUMAN antibody; MK1 antibody; NEGF 2 antibody; NEGF2 antibody; Neurite growth promoting factor 2 antibody; Neurite outgrowth promoting protein antibody; Neurite outgrowth-promoting factor 2 antibody; Neurite outgrowth-promoting protein antibody; Retinoic acid inducible factor antibody
Belongs to the pleiotrophin family.
Expressed in various tumor cell lines. In insulinoma tissue predominantly expressed in precancerous lesions.
Midkine, or MK, is a heparin-binding molecule involved in the regulation of growth and differentiation during embryogenesis. MK expression is tightly regulated during embryonic development by steroid receptors of the retinoic acid superfamily. The mature human MK protein is 118 amino acids in length and contains five intrachain disulfide bonds. MK is a non-glycosylated protein that shows greater than 87% identity between human and mouse. The carboxy-terminus of MK contains the principle heparin-binding site and the molecule’s neurite-promoting sequences; both the amino- and carboxy-terminal sequences are required for the molecule’s neurotrophic properties. An association between overexpression of MK and colon adenocarcinoma has been shown in families suffering from familial polyposis. In addition, MK functions to enhance the activity of plasminogen activator (PA).