MICA Mouse Monoclonal Antibody [A4C5] (HA600002)

UNIPROT #

Q29983

PROTEIN NAME

MICA

SYNONYMS

HLA class I antigen antibody;FLJ36918 antibody;FLJ60820 antibody;MGC111087 antibody;MGC21250 antibody;MHC class I chain related gene A protein antibody;MHC class I chain related protein A antibody;MHC class I chain related protein A HLA B HLA C antibody;MHC class I polypeptide related sequence A antibody;MHC class I polypeptide-related sequence A antibody;MHC class I related protein antibody;MIC A antibody;MIC-A antibody;micA antibody;MICA_HUMAN antibody;OTTHUMP00000029088 antibody;OTTHUMP00000044528 antibody;OTTHUMP00000165170 antibody;OTTHUMP00000165172 antibody;PERB11.1 antibody;Stress inducible class I homolog antibody

SUBCELLULAR LOCATION

Cell membrane, Cytoplasm, Membrane.

FUNCTION

MHC class I polypeptide–related sequence A (MICA) is a highly polymorphic cell surface glycoprotein encoded by the MICA gene located within MHC locus. MICA is related to MHC class I and it has similar domain structure, however, it is not associated with β2-microglobulin nor binds peptides as conventional MHC class I molecules do. MICA rather functions as a stress-induced ligand (as a danger signal) for integral membrane protein receptor NKG2D ("natural-killer group 2, member D"). MICA is broadly recognized by NK cells, γδ T cells, and CD8+ αβ T cells which carry NKG2D receptor on their cell surface and which are activated via this interaction.