Recombinant Rabbit monoclonal primary
MHC Class II Recombinant Rabbit Monoclonal Antibody [JA10-94] (ET1704-13)
Human tonsil tissue, human spleen tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
MHC Class II
D6S221E antibody; DMA antibody; DMB antibody; DP beta 1 antibody; DP beta 1 chain antibody; DP(W4) beta chain antibody; DPB 1 antibody; DPB1 antibody; DPB1_HUMAN antibody; DRB antibody; H2Ea antibody; HLA class II histocompatibility antigen antibody; HLA class II histocompatibility antigen DM beta chain antibody; HLA class II histocompatibility antigen, DP beta 1 chain antibody; HLA class II histocompatibility antigen, DP(W4) beta chain antibody; HLA DMB antibody; HLA DP1A antibody; HLA DPB1 antibody; HLA SB alpha chain antibody; HLA-A antibody; HLA-A histocompatibility type antibody; HLA-DP antibody; HLA-DP histocompatibility type, beta-1 subunit antibody; HLA-DP1B antibody; HLA-DPB antibody; HLA-DPB1 antibody; HLADM antibody; HLADP1B antibody; HLASB antibody; HLASB histocompatibility type antibody; Human MHC class II HLA SB alpha antibody; LA class II histocompatibility antigen DP alpha 1 chain antibody; Major histocompatibility complex class II antibody; Major histocompatibility complex class II DP alpha 1 antibody; Major histocompatibility complex class II DP beta 1 antibody; Major histocompatibility complex, class I, A antibody; MHC class II antigen DMB antibody; MHC class II antigen DPB1 antibody; MHC class II DP3 alpha antibody; MHC class II DPA1 antibody; MHC class II HLA-DP-beta-1 antibody; MHC DPB1 antibody; MHC HLA DPB1 antibody; PLT1 antibody; Primed lymphocyte test 1 antibody; RING6 antibody; RING7 antibody
Belongs to the MHC class II family.
Cell membrane. Endoplasmic reticulum membrane.
Major histocompatibility complex (MHC) molecules, also designated human leukocyte antigen (HLA) molecules, are cell-surface receptors that bind foreign peptides and present them to T lymphocytes. MHC class I molecules consist of two polypeptide chains, an α or heavy chain and β-2-Microglobulin, a non-covalently associated protein. Cytotoxic T lymphocytes bind antigenic peptides presented by MHC class I molecules. Antigens that bind to MHC class I molecules are typically eight to ten residues in length and are stabilized in a peptide binding groove. MHC class II molecules are encoded by polymorphic MHC genes and consist of a non-covalent complex of an α and β chain. Helper T lymphocytes bind antigenic peptides presented by MHC class II molecules. MHC class II molecules bind 13-18 amino acid antigenic peptides. Accumu-lating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM and -DO molecules regulate binding of exogenous peptides to class II molecules (HLA-DR) by sustaining a conformation that favors peptide exchange. The differential structural properties of MHC class I and class II molecules account for their respective roles in activating different populations of T lymphocytes.