Lane 1: Hela
Lane 2: MCF-7
Lane 3: Daudi
Lane 4: Raji
Lane 5: SK-BR-3
Lane 6: SKOV3
Lane 7: Human liver
Lane 8: Human kidney
Lane 9: Human thymus
Lane 10: Human placentae
Rabbit polyclonal primary
MGMT Rabbit Polyclonal Antibody (ER40104)
Synthetic peptide within residues of mgmt aa 158-207 / 207.
MCF-7, Hela, Dauai, Raji, A172,human kidney tissue, human liver tissue, human thymus tissue, human placentae tissue, Jurkat,SK-BR-3 ,SKOV3,human tonsil tissuehuman colon carcinoma tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Peptide affinity purified
6 O methylguanine DNA methyltransferase antibody; 6-O-methylguanine-DNA methyltransferase antibody; Agat antibody; AGT antibody; AI267024 antibody; EC 184.108.40.206 antibody; Methylated DNA protein cysteine methyltransferase antibody; Methylated-DNA--protein-cysteine methyltransferase antibody; Methylguanine DNA methyltransferase antibody; MGC107020 antibody; MGMT antibody; MGMT_HUMAN antibody; O 6 methylguanine DNA alkyltransferase antibody; O 6 methylguanine DNA methyltransferase antibody; O-6-methylguanine-DNA methyltransferase antibody; O-6-methylguanine-DNA-alkyltransferase antibody
Belongs to the MGMT family.
MGMT (O-6-methylguanine-DNA methyltransferase) is a DNA repair enzyme that participates in a suicide reaction that specifically removes methyl or alkyl groups from the O (6) position of guanine, restoring guanine to its normal form without causing DNA breaks. MGMT protects cells from alkylating toxins, and is an important factor in drug resistance to alkylating therapeutic agents. It is ubiquitously expressed in normal human tissues and is overexpressed in many types of human tumors, but epigenetically silenced in other tumors. MGMT silencing is a marker associated with poor prognosis, but is a good predictive marker for response to alkylating agent chemotherapy.