MGMT Recombinant Rabbit Monoclonal Antibody [JE31-37] (ET7110-52)

UNIPROT #

P16455

PROTEIN NAME

MGMT

SYNONYMS

6 O methylguanine DNA methyltransferase antibody;6-O-methylguanine-DNA methyltransferase antibody;Agat antibody;AGT antibody;AI267024 antibody;EC 2.1.1.63 antibody;Methylated DNA protein cysteine methyltransferase antibody;Methylated-DNA--protein-cysteine methyltransferase antibody;Methylguanine DNA methyltransferase antibody;MGC107020 antibody;MGMT antibody;MGMT_HUMAN antibody;O 6 methylguanine DNA alkyltransferase antibody;O 6 methylguanine DNA methyltransferase antibody;O-6-methylguanine-DNA methyltransferase antibody;O-6-methylguanine-DNA-alkyltransferase antibody

SEQUENCE SIMILARITIES

Belongs to the MGMT family.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

MGMT is a protein that in humans is encoded by the O6-methylguanine DNA methyltransferase (MGMT) gene. O6-methylguanine DNA methyltransferase is crucial for genome stability. It repairs the naturally occurring mutagenic DNA lesion O6-methylguanine back to guanine and prevents mismatch and errors during DNA replication and transcription. Accordingly, loss of MGMT increases the carcinogenic risk in mice after exposure to alkylating agents. The two bacterial isozymes are Ada and Ogt. Although alkylating mutagens preferentially modify the guanine base at the N7 position, O6-alkyl-guanine is a major carcinogenic lesion in DNA. This DNA adduct is removed by the repair protein O6-alkylguanine DNA alkyltransferase through an SN2 mechanism. This protein is not a true enzyme since it removes the alkyl group from the lesion in a stoichiometric reaction and the active enzyme is not regenerated after it is alkylated (referred to as a suicide enzyme). The methyl-acceptor residue in the protein is a cysteine.