Metadherin / LYRIC Rabbit Polyclonal Antibody (R1511-10)

UNIPROT #

Q86UE4

PROTEIN NAME

Metadherin(LYRIC)

SYNONYMS

3D3 antibody;3D3/LYRIC antibody;AEG 1 antibody;AEG-1 antibody;AEG1 antibody;Astrocyte elevated gene 1 antibody;Astrocyte elevated gene-1 protein antibody;LYRIC antibody;LYRIC/3D3 antibody;LYRIC_HUMAN antibody;Lysine rich CEACAM1 associated protein antibody;Lysine rich CEACAM1 co isolated protein antibody;Lysine-rich CEACAM1 co-isolated protein antibody;Metadherin antibody;Metastasis adhesion protein antibody;MTDH antibody;Protein LYRIC antibody

TISSUE SPECIFICITY

Widely expressed with highest levels in muscle-dominating organs such as skeletal muscle, heart, tongue and small intestine and in endocrine glands such as thyroid and adrenal gland. Overexpressed in various cancers including breast, brain, prostate, melanoma and glioblastoma multiforme.

SUBCELLULAR LOCATION

Endoplasmic reticulum membrane. Nucleus.

FUNCTION

MTDH (metastasis adhesion protein), also known as astrocyte elevated gene-1 protein (AEG1) or lysine-rich CEACAM1 co-isolated protein (LYRIC), is a 582 amino acid single-pass membrane protein. Overexpressed in various cancers, MTDH activates the transcription factor NFκB and promotes anchorage-independent growth of immortalized astrocytes and melanocytes, which are key components of tumor growth. MTDH is also thought to enhance the seeding of tumor cells to the target organ endothelium. Localized mainly to the endoplasmic reticulum membrane, MTDH also translocates from the cytoplasm to the nucleus when induced by TNFα. MTDH also localizes to tight junctions (TJ) during the maturation of TJ complexes in epithelial cells. MTDH is found at highest levels in heart, skeletal muscle, tongue and small intestine.