Met (c-Met) Rabbit Polyclonal Antibody (HA500242)

UNIPROT #

P08581

PROTEIN NAME

Met (c-Met)

SYNONYMS

AUTS9 antibody;c met antibody;D249 antibody;Hepatocyte growth factor receptor antibody;HGF antibody;HGF receptor antibody;HGF/SF receptor antibody;HGFR antibody;MET antibody;Met proto oncogene antibody;Met proto oncogene tyrosine kinase antibody;MET proto oncogene, receptor tyrosine kinase antibody;Met proto-oncogene (hepatocyte growth factor receptor) antibody;Met proto-oncogene antibody;Met protooncogene antibody;MET_HUMAN antibody;Oncogene MET antibody;Par4 antibody;Proto-oncogene c-Met antibody;RCCP2 antibody;Scatter factor receptor antibody;SF receptor antibody;Tyrosine-protein kinase Met antibody

SUBCELLULAR LOCATION

Membrane; Secreted.

FUNCTION

This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers.