Mesothelin Rabbit Polyclonal Antibody (ER1803-76)

UNIPROT #

Q13421

PROTEIN NAME

Mesothelin

SYNONYMS

CAK 1 antibody;CAK1 antibody;CAK1 antigen antibody;cleaved form antibody;Megakaryocyte potentiating factor antibody;Mesothelin antibody;Mesothelin isoform 1 precursor antibody;MPF antibody;Msln antibody;MSLN_HUMAN antibody;Pre pro megakaryocyte potentiating factor antibody;Pre-pro-megakaryocyte-potentiating factor antibody;SMR antibody;SMRP antibody;Soluble MPF mesothelin related protein antibody

SEQUENCE SIMILARITIES

Belongs to the mesothelin family.

TISSUE SPECIFICITY

Expressed in lung. Expressed at low levels in heart, placenta and kidney. Expressed in mesothelial cells. Highly expressed in mesotheliomas, ovarian cancers, and some squamous cell carcinomas (at protein level).

POST-TRANSLATIONAL MODIFICATION

Both MPF and the cleaved form of mesothelin are N-glycosylated.; Proteolytically cleaved by a furin-like convertase to generate megakaryocyte-potentiating factor (MPF), and the cleaved form of mesothelin.

SUBCELLULAR LOCATION

Cell membrane, Golgi apparatus, Membrane, Secreted.

FUNCTION

This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. Mesothelin is over expressed in several human tumors, including mesothelioma, ovarian cancer, pancreatic adenocarcinoma and cholangiocarcinoma. The interaction between mesothelin and MUC16 (also known as CA125) may facilitate the implantation and peritoneal spread of tumors by cell adhesion. Dr. Mitchell Ho and colleagues at the National Cancer Institute identified the region (residues 296-359) consisting of 64 amino acids at the N-terminus of cell surface mesothelin as the functional binding domain for MUC16.