MERTK Recombinant Rabbit Monoclonal Antibody [SR29-07] (ET1602-21)

UNIPROT #

Q12866

PROTEIN NAME

MERTK

SYNONYMS

c MER antibody;c mer proto oncogene tyrosine kinase antibody;c-mer antibody;cMER antibody;cmer protooncogene tyrosine kinase antibody;Eyk antibody;MER antibody;MER receptor tyrosine kinase antibody;MERK antibody;MERPEN antibody;Mertk antibody;MERTK c-mer proto-oncogene tyrosine kinase antibody;MERTK_HUMAN antibody;MGC133349 antibody;nmf12 antibody;Nyk antibody;Proto oncogene tyrosine protein kinase MER antibody;Proto oncogene tyrosine protein kinase MER precursor antibody;Proto-oncogene c-Mer antibody;Receptor tyrosine kinase MerTK antibody;RP38 antibody;STK kinase antibody;Tyrosine-protein kinase Mer antibody

SEQUENCE SIMILARITIES

Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.

TISSUE SPECIFICITY

Not expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines. Highly expressed in testis, ovary, prostate, lung, and kidney, with lower expression in spleen, small intestine, colon, and liver.

POST-TRANSLATIONAL MODIFICATION

Autophosphorylated on Tyr-749, Tyr-753 and Tyr-754 in the activation loop allowing full activity. Autophosphorylated on Tyr-872 leading to recruitment of downstream partners of the signaling cascade such as PLCG2 (By similarity).

SUBCELLULAR LOCATION

Membrane.

FUNCTION

MerTK, also called c-Mer, is a member of the Mer/Axl/Tyro3 receptor kinase family. It is a 984 residue transmembrane protein made up of one tyrosine kinase domain, two Fibronectin type-III domains and two immunoglobulin-like C2-type domains. MerTK is the mammalian ortholog of the chicken retroviral oncogene product v-Eyk. This protein plays a critical role in macrophage activation, platelet aggregation, clot stability and the efficient removal of apoptotic cells. Specifically, MerTK acts as a signaling molecule, triggering outer segment ingestion in the retinal pigment epithelium (RPE) phagocytic process. Evidence suggests that MerTK signals via interaction with phosphatidylinositol-specific phospholipase C 2 (PI-PLC 2). When the gene encoding for MerTK is mutated, the RPE phagocytosis pathway is disrupted and autosomal recessive retinitis pigmentosa (RP) may result, leading to degeneration of retinal photoreceptor cells.